Agents Mulder and Scully return after 13 years to investigate a government conspiracy at the behest of a popular web-TV-show host, who introduces them to a woman who claims she's an alien abductee and shares startling news with them.
Guest Stars:
William B. Davis, Annet Mahendru, Giacomo Baessato, Hiro Kanagawa, Rance Howard
When Mulder and Scully try to discover what unseen force may have driven a scientist to commit suicide, they turn up a laboratory where extreme genetic experimentation has bred subjects possessing dangerous powers.
Guest Stars:
Jonathan Whitesell, Rebecca Wisocky, Doug Savant, Aaron Douglas, Vik Sahay
Mulder and Scully investigate a dead body in the woods, and try to determine whether it was the work of a serial killer, an animal or a mysterious creature seen by eyewitnesses. Meanwhile, a disillusioned Mulder confronts some of his own demons.
Guest Stars:
Mulder and Scully investigate the murder of a city official, a crime that doesn't appear to have been committed by human hands. Meanwhile, Scully faces deeply emotional feelings about the child she gave up for adoption.
Guest Stars:
Tim Armstrong, Daryl Shuttleworth, Peggy Jo Jacobs, Alessandro Juliani, Chris Shields
Scully and Mulder investigate when an art gallery displaying offensive artwork is bombed, and need to discover a way to communicate with the comatose perpetrator to try and prevent a future attack.
Guest Stars:
William B. Davis, Eric Breker, Stephen Lobo, Shaine Jones, Janet Kidder
The season concludes with people all across the country falling gravely ill. A widespread panic develops and Scully looks within to find a cure. Meanwhile, Mulder confronts the man he believes to be behind it all, but another figure from Mulder and Scully's past may prove to be the key to their salvation.
Guest Stars:
Rhys Darby, Kumail Nanjiani, Tyler Labine, D.J. 'Shangela' Pierce, Richard Newman
Annabeth Gish, William B. Davis, Julian Christopher, Aliza Vellani, Mik Byskov

22 Episodes