Season 1

The Animal Liberation Alliance, a terrorist group, raids a research institute and takes away a pregnant chimpanzee. Fifteen years later, Charlie, the half-human, half-chimpanzee Humanzee born that night enrolls into high school. He befriends Lucy, but little do they know how fragile their peaceful days really are.

The ALA attacks New York City, killing several people in a bombing. When news about Charlie's past ties to the ALA resurfaces, the town grows suspicious of his terrorist connections. Unfazed, Charlie goes to school as usual, not realizing what the ALA has in store for him as a mysterious man approaches Lucy.

Lucy visits Eva, the chimpanzee who gave birth to Charlie, at The Kornberg Primate Research Institute. There, she meets Dr. Fowler who tells her a few secrets about Charlie's birth. She later joins Charlie's family for dinner as Hannah celebrates Charlie's first friend, unaware that the ALA members are lying in wait.

Charlie suddenly goes missing. While Bert and Hannah search everywhere for him, Charlie is calmly confronting Rivera, Lippman and Min-su of the ALA. He gives them an ultimatum and things seem to be heading towards a peaceful conclusion until Rivera makes a drastic move.