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In the second season, powerhouse physician Dr. Amy Larsen continues to rebuild her life after eight years of her memory were erased. No longer Chief of Internal Medicine at Westside Hospital, Amy must restart her medical journey as an Intern in the hopes of becoming the doctor she once was. She'll confront hard truths about her missing years, work to repair fractured relationships, and seek to reconcile the person she used to be with the one everyone else has come to know.
Amy's past comes back to haunt her when a desperate father sacrifices everything to secure his daughter's heart transplant.

Amy struggles with memories during treatment of an expectant mother's puzzling illness. Her mentor Dr. Joan Ridley makes a visit to Westside.
With the search underway to find out the truth about Amy's hacked accounts, she and Sonya butt heads while treating a homeless patient with a crush injury who was dumped in front of Westside Hospital. Jake and TJ help a distraught mother figure out why her daughter is in a coma. Hannah cares for a charming high school athlete, while working with Charlie to cover their tracks by infiltrating the hospital computer system. Unfortunately, those efforts result in major collateral damage.
The search for Amy's hacker intensifies when the hospital finally brings in the FBI. Hannah, devastated by the death of her patient, works with Amy to treat a sick older man whose daughter believes has been poisoned. Meanwhile, Sonya and TJ examine middle school kids for scoliosis, and discover a child with a different ailment and a home situation that may have caused it to get much worse.
Charlie fights for his life at Westside with Hannah by his side. The Board launches an internal investigation into Brian Clark's resignation, putting everyone in the hot seat and motivating Amy to figure out what happened before the hospital can make her a scapegoat. A familiar face returns to Westside and Amy is not happy about it.
The race for Chief resident intensifies as Joan tasks Amy and Sonya with evaluating each other's case work. Amy tends to a politician with a disability whose dire health complications threaten to interrupt a crucial vote. Sonya struggles to find a solution to her combative patient's excruciating abdominal pain. Michael's parents come to town causing more family drama for him and Katie.
A shocking turn of events ensues when Amy and Jake treat an expectant mother injured during a robbery. Michael is challenged to open up when Katie's therapist invites him and Amy to a session. TJ and Sonya help Julie navigate a mysterious illness and an unexpected romance.