Season 25

Nick, and his girlfriend, Emily, are heavily addicted to carfentanil. Nick's family has stepped up to offer their son -- and Emily -- a final shot at getting clean.

Three addicted brothers have turned their childhood home into a hellish drug den where death is constantly at the door. As the brothers continue to struggle with the extreme abuse they suffered growing up, their mother sinks under the stress of continuous using, violent fighting and overdoses that have become the norm.

Jessica, a former high school beauty queen, is now just a shadow of her former self; as a teen mom, Jessica went to college and did her best to provide for her children, but a toxic ex introduced her to the drug trade.

Nineteen-year-old Melissa, once a star athlete who spent her free time volunteering, experiments with drugs and alcohol is eventually lured into the dark world of sex trafficking after experiencing a sexual assault as a young teen.

Tim and Jessica, both 43, first met in the 6th grade but three years ago they reconnected on Facebook and embarked on a chaotic.

When devoted animal rescuer, Shannon, develops a drug addiction, the one thing she can't seem to rescue is herself; childhood trauma, sexual abuse and toxic relationships become an explosive mix.

For Gabby and Patryk, it was love at first sight, 9 months later, Gabby gave birth to their daughter; they both happen to be heavily addicted to drugs, and the drug dealing lifestyle; their using has cost them custody of their daughter.

Disappointed by his own failed athletic career, Greg's father had found a new life in drugs and alcohol, and ultimately introduced his own son to crack cocaine; now 31, Greg is addicted to a deadly mix of fentanyl and meth and living on the streets.

Erika and Joey used meth together on their first date, beginning a drug-fueled romance; Joey's family refuses to be around Erika, leading to tension in the relationship; both families must come together to save them.

Josh's struggle with addiction threatens to destroy him; separated from his father and bullied for years, he's lost his way, leaving his family to fight for his survival amidst the chaos and violence fueled by crack cocaine.

Tommy and Melly, both 19, have had a troubled life for two people so young; both grew up in hardworking families, surrounded by a lot of love, but also a lot of pain; they are spiraling into fentanyl and meth addiction.

Cassandra and Steven met in a rehabilitation center five and a half years ago; after leaving treatment, they moved in together and shortly thereafter were engaged to be married; both quickly relapsed, spiraling deep into addiction.

After Shantell overdosed on the drugs Garrett supplied her with, he saved her life and the two fell in love; years later, both Garrett and Shantell are addicted to fentanyl and meth and their families believe they will die if they don't get help now.

Carlee and Cody believe their addiction is a passing phase; with the constant enabling from Cody's father, they have no reason to quit this lifestyle and their families fear that their relationship will end tragically.

Corinne and Joey live together in Northern California where they scrounge money for meth, smoke whatever they can get their hands on, and profess their undying love for one another.

Danielle is addicted to fentanyl and struggles to survive in the streets while her children live in fear that the next time they see her will be at the local morgue.

Cody and Erin have a loving relationship, primarily founded on their addiction to drugs; they were once a couple of bright kids with decent futures ahead of them, but hard circumstances and family loss have derailed them.

Golden child Tristan excelled at academics and the arts, winning scholarships and lead parts in theater productions; after a sexual assault at university, he spiraled into severe alcoholism; his liver is failing, his family fears for his life.