Season 1

Spring has sprung in Michigan, and Barn Sanctuary prepares to open the pastures; Dan and Kelley head to Iowa to rescue a lamb called Ginger who is in need of major medical attention, and Dan's twin Chris is home and ready to be put to work.

A cow called Buttercup comes to Barn Sanctuary, but the team is concerned about her feisty behavior toward the rest of the herd; Ginger the lamb battles a life-threatening infection, and Bart the rowdy rooster is in need of a vet visit.

Dan heads to Chicago to give cockfighting roosters a second chance; then the crew worries if DJ the cow's unruly behavior will be welcomed by the rest of the herd.

Chris experiences his first rescue and saves two goats called Hugo and Emmy who are in need serious medical attention; Joey the calf returns after a series of surgeries, and Lola the kid goat is surprised with a prosthetic.

As summer arrives, the team hosts a carwash fundraiser to help the cows and donkeys receive medication; a covert mission to save KJ, an injured goat kid; and a donkey called Mary Pete needs medical attention.

The sanctuary welcomes a blind goat called Charlie and two lovable ducklings that need help to learn how to swim; a tussle between pigs June and Jasper ensues during routine tusk and nail trimming, while Ginger the goat embraces her new prosthetics.

The barn partners with Michigan Humane Society to find forever homes for four neglected calves; they also welcome a litter of piglets, and Chris is tasked to build a playground for the goats.

A cow called Dwight is ready to conquer his pain from a leg injury and heads to Indiana for hydrotherapy; Lola the goat is gifted with a prosthetic and is ready to walk again, while Dan takes in over a dozen exotic farm animals.

Dan and Chris head across Lake Michigan to adopt two Mangalica piglets; a rooster called Bart undergoes surgery to remove his spur, and Steve the goat is gifted with pool noodles to protect the other animals from his rage.

After a year in the making, the Barn Sanctuary pigs are ready to move into their pig palace; the turkeys are gifted with musical instruments, and after Andy the cow passes, the staff has a memorial in his honor.

In North Carolina rescuing a group of pigs from horrific living conditions and discovering that one of the pigs is pregnant; the organization's new sign is displayed, making their transformation official.